您的位置：首页 > 产品中心 > Anti-AMSH-LP / STAMBPL1 (C-terminal) antibody produced in rabbit
Anti-AMSH-LP / STAMBPL1 (C-terminal) antibody produced in rabbit
产品别名
Anti-AMSH-LP / STAMBPL1 (C-terminal) antibody produced in rabbit
Anti-ALMalpha
Anti-associated molecule with the SH3 domain of STAM (AMSH) like protein
Anti-AMSH-FP
Anti-AMSH-like protease
Anti-STAM binding protein-like 1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | AMSH-like protein (AMSH-LP), also known as STAM-binding protein-like 1 (STAMBPL1), is a close homolog of AMSH (Associated Molecule with the SH3 domain of STAM). AMSH and AMSH-LP belong to the JAMM (JAB1/MPN/Mov34 metalloenzyme) domain metalloprotease family of Zn2+-dependent deubiquitinating enzymes (DUBs). AMSH-LP contains a nuclear localization signal (NLS), an Mpr/Pad1/N-terminal (MPN) domain, and a Jab1/MPN domain metalloenzyme (JAMM) motif. |
| Application【应用】 | Anti-AMSH-LP / STAMBPL1 (C-terminal) antibody has been used in
|
| Biochem/physiol Actions【生化/生理作用】 | AMSH-like protein (AMSH-LP) and Associated Molecule with the SH3 domain of STAM (AMSH) proteins are involved in the deubiquitination of endosomal proteins and specifically cleave K-63-linked (Lys-63) polyubiquitin chains. AMSH-LP, interacts with clathrin heavy chain and this interaction is essential for its endosomal localization. AMSH-LP, interacts with clathrin heavy chain and this interaction is essential for its endosomal localization. It also positively regulatestransforming growth factor beta (TGF-β) signaling through interaction with inhibitory I-SMADs (inhibitory-Mothers against decapentaplegic). |
| Physical form【外形】 | Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | rabbit |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | affinity isolated antibody |
| antibody product type | primary antibodies |
| clone【克隆】 | polyclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~50 kDa |
| species reactivity | monkey, bovine, canine, mouse, rat, human |
| packaging【包装】 | antibody small pack of 25 μL |
| concentration【浓度】 | ~1 mg/mL |
| technique(s) | indirect immunofluorescence: 5-10 μg/mL using human HeLa cells western blot: 2.5-5.0 μg/mL using whole extracts of mouse NIH-3T3 cells western blot: 5-10 μg/mL using using whole extracts of rat NRK cells |
| UniProt accession no.【UniProt登记号】 | Q96FJ0 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... STAMBPL1(57559) mouse ... Stambpl1(76630) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
