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AM6545
产品别名
1245626-05-4
AM6545
5-(4-[4-cyanobut-1-ynyl]phenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(1,1-dioxo-thiomorpholino)-1H-pyrazole-3-carboxamide
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C26H23Cl2N5O3S |
| Molecular weight | 556.46 |
| MDL number | MFCD19053178 |
| PubChem Substance ID【PubChem化学物质编号】 | 329770727 |
| NACRES | NA.77 |
| General description【一般描述】 | AM6545 is a cannabinoid (CB1) receptor antagonist. |
| Biochem/physiol Actions【生化/生理作用】 | AM6545 helps in decreasing the development of albuminuria, inflammation and expression of markers of fibrosis. It also helps in the down-regulation of nephrin and podocin. It has the ability to repress the ingestion of food and food-reinforced behaviour. AM6545 is a peripheral CB1 cannabinoid receptor antagonist and appetite suppressant. |
| Features and Benefits【特点和优势】 | This compound is featured on the Cannabinoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: >25 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(cc3)C#CCCC#N)C(=O)NN4CCS(=O)(=O)CC4 |
| InChI | 1S/C26H23Cl2N5O3S/c1-18-24(26(34)31-32-13-15-37(35,36)16-14-32)30-33(23-11-10-21(27)17-22(23)28)25(18)20-8-6-19(7-9-20)5-3-2-4-12-29/h6-11,17H,2,4,13-16H2,1H3,(H,31,34) |
| InChI key | XBHQLFVDGLPBCK-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
