2OHOA

C₁₈H₃₄O₃

298.46

MFCD07778553

329825264

NA.77

2OHOA has been used as:

• a modulator of the sphingolipid and glycerophospholipid pathway to study its effects on myelination in mice Charcot–Marie–Tooth type 1A (CMT1A) myelinopathy and myelinating dorsal root ganglia cultures
• in biophysical studies to study its effects on artificial membranes
• to study its interactions with major membrane lipid films

2-Hydroxy oleic acid (2OHOA) is a derivative of oleic acid. It plays a role in membrane organization, alterations in membrane fluidity, an increase of the tendency to form non-lamellar structures, and remodeling of microdomains by interacting with the lipids in membranes of pathological cells.
2OHOA induces cell cycle arrest and apoptosis in several cancer cell lines, including glioma, leukemia, breast and colon cancer lines. 2OHOA increases sphingomyelin (SM) levels in the membranes of tumor cells, which typically display decreased SM membrane content, and remodeled membranes, compared with normal cells. The compound has no effect on SM levels in non-cancer cells.

100

≥98% (HPLC)

protect from light

white to tan

DMSO: >20 mg/mL

room temp

CCCCCCCC\C=C/CCCCCCC(O)C(O)=O

1S/C18H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17(19)18(20)21/h9-10,17,19H,2-8,11-16H2,1H3,(H,20,21)/b10-9-

JBSOOFITVPOOSY-KTKRTIGZSA-N

5, 25 mg in glass bottle

GHS05

Danger

H318

P280 - P305 + P351 + P338

Eye Dam. 1

13 - Non Combustible Solids

WGK 3