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Z-脯氨酸
Z-Pro-prolinal
产品别名
88795-32-8
Z-脯氨酸
Z-Pro-prolinal
Phenylmethyl (2S)-2-[(2S)-2-formylpyrrolidine-1-carbonyl]pyrrolidine-1-carboxylate
ZPP
Cbz-Pro-Prolinal
Z-pro-pro-CHO
Z-prolyl-prolinal
Z-Pro-Pro-CHO, Z-PP-CHO
N-Benzyloxycarbonyl-L-prolyl-L-prolinal
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H22N2O4 |
| Molecular weight | 330.38 |
| NACRES | NA.77 |
| Application【应用】 | Z-Pro-prolinal was used to inhibit activation of rekallikrein in Prolylcarboxypeptidase assay in HUVECs. ZPP was also used in assays to identify enzymes important in the processing of angiotensin peptides in human glomerular endothelial cells. |
| Biochem/physiol Actions【生化/生理作用】 | Z-Pro-prolinal is a potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki = 1 nM. POP has been connected to memory and mood through regulation of the brain levels of its peptide substrates, which include AVP, substance P, neurotensin and TRH and is a potential target in cognitive function, memory, and neurodegenerative disorders such as amnesia, Alzheimer′s disease, and depression. POP has recently been reported to be involved in the release of the tetrapeptide acetyl-N-Ser-Asp-Lys-Pro (Ac-SDKP) from its precursor, 43-mer thymosin β4 (Tβ4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | white to tan |
| solubility【溶解性】 | DMSO: ≥10 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| InChI | 1S/C18H22N2O4/c21-12-15-8-4-10-19(15)17(22)16-9-5-11-20(16)18(23)24-13-14-6-2-1-3-7-14/h1-3,6-7,12,15-16H,4-5,8-11,13H2/t15-,16-/m0/s1 |
| InChI key | ORZXYSPOAVJYRU-HOTGVXAUSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 - H319 |
| Precautionary Statements | P301 + P312 + P330 - P305 + P351 + P338 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
