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TUG-424
产品别名
1082058-99-8
TUG-424
3-(4-(o-Tolylethynyl)phenyl)propanoic acid
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C18H16O2 |
| Molecular weight | 264.32 |
| MDL number | MFCD12912449 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826854 |
| Biochem/physiol Actions【生化/生理作用】 | TUG-424 is expected to be useful in the exploration of FFA1 and may also be valuable as a lead structure for new potential antidiabetic therapeutics. TUG-424 significantly increased glucose-stimulated insulin secretion at 100 nM and may serve to explore the role of FFA1 in metabolic diseases such as diabetes or obesity. It enhanced glucose-stimulated insulin secretion in a rat beta-cell line already at 100 nM and from isolated mouse islets through FFA1. GPR40 (now FFA1) was formerly an orphan GPCR whose endogenous ligands have recently been identified as free fatty acids (FFAs). The receptor appears to be involved in the pathophysiology of type 2 diabetes and is a drug target because of its role in FFA-mediated enhancement of glucose-stimulated insulin release. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| solubility【溶解性】 | DMSO: >10 mg/mL H2O: insoluble |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cc1ccccc1C#Cc2ccc(CCC(O)=O)cc2 |
| InChI | 1S/C18H16O2/c1-14-4-2-3-5-17(14)12-10-15-6-8-16(9-7-15)11-13-18(19)20/h2-9H,11,13H2,1H3,(H,19,20) |
| InChI key | FODHWOBAQBTTFS-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07,GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H319 - H410 |
| Precautionary Statements | P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391 |
| Hazard Classifications【危险分类】 | Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | dust mask type N95 (US), Eyeshields, Gloves |
