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Terameprocol
产品别名
24150-24-1
Terameprocol
rel-4-[(2R,3S)-4-(3,4-Dimethoxyphenyl)-2,3-dimethylbutyl]-1,2-dimethoxybenzene
tetra-O-methyl-NDGA
EM-1421
tetramethyl NDGA
M4N
Tetra-O-methyl nordihydroguaiaretic acid
tetramethyl Nordihydroguaiaretic Acid
2,3-Dimethyl-1,4-bis-(3,4-dimethoxyphenyl)butane
TMNDGA
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C22H30O4 |
| Molecular weight | 358.47 |
| MDL number | MFCD11113155 |
| PubChem Substance ID【PubChem化学物质编号】 | 329826768 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Terameprocol is a synthetic derivative of NDGA, a non-selective lipoxygenase inhibitor. It inhibits Sp1 transcription factor binding at the HIV long terminal repeat promoter and at the α-ICP4 promoter, a gene essential for HSV replication, with IC50 values of 11 and 43.5 μM respectively. TMNDGA induces growth arrest and apoptosis by suppressing Sp1-dependent Cdc2 and survivin gene expression giving rise to its antitumorigenic activity. The in vivo growth of xenografts in numerous human tumor types was suppressed upon treatment with TMNDGA It also inhibits the growth of murine and human melanomas and human colon cancer in vivo without causing other tissue toxicity. Terameprocol is known to reduce angiogenesis1. |
| Preparation Note【制备说明】 | Terameprocol is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: ≥10 mg/mL |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | COc1ccc(C[C@H](C)[C@H](C)Cc2ccc(OC)c(OC)c2)cc1OC |
| InChI | 1S/C22H30O4/c1-15(11-17-7-9-19(23-3)21(13-17)25-5)16(2)12-18-8-10-20(24-4)22(14-18)26-6/h7-10,13-16H,11-12H2,1-6H3/t15-,16+ |
| InChI key | ORQFDHFZSMXRLM-IYBDPMFKSA-N |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS09 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H410 |
| Precautionary Statements | P273 - P501 |
| Hazard Classifications【危险分类】 | Aquatic Acute 1 - Aquatic Chronic 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
