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产品别名
Raltitrexed
ICI-D-1694
ZD-1694
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C21H22N4O6S |
| Molecular weight | 458.49 |
| PubChem Substance ID【PubChem化学物质编号】 | 329824044 |
| Biochem/physiol Actions【生化/生理作用】 | Raltitrexed is a folate-based inhibitor of thymidylate synthase (TS) that is rapidly and extensively metabolized to its more potent polyglutamate derivatives. By inhibiting the formation of precursor pyrimidine nucleotides, raltitrexed prevents the formation of DNA and RNA, which are required for the growth and survival of both normal cells and cancer cells. |
| Features and Benefits【特点和优势】 | This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | solid |
| color【颜色】 | off-white to light yellow |
| solubility【溶解性】 | H2O: ≥10 mg/mL DMSO: ≥40 mg/mL |
| originator【创始人】 | AstraZeneca |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O=C1NC(C)=NC2=C1C=C(CN(C3=CC=C(C(N[C@H](CCC(O)=O)C(O)=O)=O)S3)C)C=C2 |
| packaging【包装】 | 10 mg in glass bottle 50 mg in poly bottle |
安全信息
| Pictograms【象形图】 | GHS06,GHS08 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H300 - H360 |
| Precautionary Statements | P201 - P301 + P310 + P330 |
| Hazard Classifications【危险分类】 | Acute Tox. 2 Oral - Repr. 1B |
| Storage Class Code【储存分类代码】 | 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 2 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges |
