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R-(+)-DIOA

产品编号:3213373
规格:≥98% (HPLC), solid
CAS NO:81166-47-4
包装规格:10 MG,50 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
321337310 MG3760
321337350 MG12080
产品别名

81166-47-4

R-(+)-DIOA

R(+)-Butylindazone

R-(+)-[(2-n-Butyl-6,7-dichloro-2-cyclopentyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C20H24Cl2O4
Molecular weight
399.31
MDL number
MFCD00069261
PubChem Substance ID【PubChem化学物质编号】
24277830
Application【应用】
R-(+)-DIOA has been used as a potassium/chloride K+-Cl- transport inhibitor to study its effects on:
  • short circuit current (Isc) in rat semicircular canal duct (SCCD) epithelium
  • uptake of grepafloxacin by THP-1 monocytes
  • the uptake of moxifloxacin by THP-1 monocytes

Biochem/physiol Actions【生化/生理作用】
[(dihydroindenyl)oxy]acetic acid (DIOA) acts as a potent inhibitor of potassium/chloride (K+–Cl) co-transporter. It does not exert its effects on bumetanimide-sensitive [Na+,K+,Cl-]-cotransport system.
产品性质
Assay【测定】
≥98% (HPLC)
form【形式】
solid
optical activity【旋光性】
[α]27/D +18.1°, c = 0.7 in methanol(lit.)
color【颜色】
white
solubility【溶解性】
H2O: insoluble <0.11 mg/mL
DMSO: >20 mg/mL
0.1 M HCl: insoluble
0.1 M NaOH: soluble
ethanol: soluble
SMILES string
CCCC[C@]1(Cc2cc(OCC(O)=O)c(Cl)c(Cl)c2C1=O)C3CCCC3
InChI
1S/C20H24Cl2O4/c1-2-3-8-20(13-6-4-5-7-13)10-12-9-14(26-11-15(23)24)17(21)18(22)16(12)19(20)25/h9,13H,2-8,10-11H2,1H3,(H,23,24)/t20-/m0/s1
InChI key
YAWWQIFONIPBKT-FQEVSTJZSA-N
packaging【包装】
10, 50 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, type N95 (US)
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