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Pimelic Diphenylamide 106

产品编号:3182173
规格:≥98% (HPLC)
CAS NO:937039-45-7
包装规格:5 MG,25 MG
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
31821735 MG1130
318217325 MG4160
产品别名

937039-45-7

Pimelic Diphenylamide 106

N1-(2-Aminophenyl)-N7-(4-methylphenyl)-heptanediamide

Compound 106

RGFA 8

TC-H 106

Inhibitor 106

结构式
基本信息
Empirical Formula【经验(实验)分子式】
C20H25N3O2
Molecular weight
339.43
MDL number
MFCD17010287
PubChem Substance ID【PubChem化学物质编号】
329825318
NACRES
NA.77
Biochem/physiol Actions【生化/生理作用】
Pimelic diphenylamides has the ability to enhance the expression of the frataxin gene in lymphocytes from Friedreich ataxia patients.
106 is a Class I HDAC inhibitor, demonstrating no activity against class II HDACs. It is a slow, tight-binding inhibitor of HDACs 1, 2, and 3, with a preference toward HDAC3 with Ki of 14 nM, 15 times lower than the Ki for HDAC1.
产品性质
Quality Level【质量水平】
100
Assay【测定】
≥98% (HPLC)
form【形式】
powder
color【颜色】
white to beige
solubility【溶解性】
DMSO: ≥15 mg/mL
storage temp.【储存温度】
2-8℃
SMILES string
Cc1ccc(NC(=O)CCCCCC(=O)Nc2ccccc2N)cc1
InChI
1S/C20H25N3O2/c1-15-11-13-16(14-12-15)22-19(24)9-3-2-4-10-20(25)23-18-8-6-5-7-17(18)21/h5-8,11-14H,2-4,9-10,21H2,1H3,(H,22,24)(H,23,25)
InChI key
WTKBRPXPNAKVEQ-UHFFFAOYSA-N
packaging【包装】
5, 25 mg in glass bottle
安全信息
Storage Class Code【储存分类代码】
13 - Non Combustible Solids
WGK
WGK 3
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