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Nilutamide

产品编号:3175155
规格:solid
CAS NO:63612-50-0
包装规格:1 G
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品编号包装单位单价(元)国内现货国外库存询价单
31751551 G1400
产品别名

63612-50-0

Nilutamide

RU-23908

5,5-Dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]-2,4-imidazolidinedione

Anandron

基本信息
Empirical Formula【经验(实验)分子式】
C12H10F3N3O4
Molecular weight
317.22
MDL number
MFCD00864670
PubChem Substance ID【PubChem化学物质编号】
24278596
NACRES
NA.77
Application【应用】
Nilutamide has been used:
  • as a nuclear androgen receptor (nAR) inhibitor to study its effects on oocyte maturation in zebrafish
  • to determine its effects on bioluminescent Saccharomyces cerevisiae bioreporters in BLYAS assay
  • as a substrate in hydrogenation reaction

Biochem/physiol Actions【生化/生理作用】
Nilutamide is a nuclear androgen receptor inhibitor. It is a nonsteroidal antiandrogen that competitively inhibits the binding of dihydrotestosterone to the androgen receptor. Nilutamide shows a therapeutic effect against prostate cancer.
Features and Benefits【特点和优势】
This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Other Notes【其他说明】
Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. N8534.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.
产品性质
Quality Level【质量水平】
200
form【形式】
solid
originator【创始人】
Sanofi Aventis
SMILES string
CC1(C)NC(=O)N(c2ccc(c(c2)C(F)(F)F)[N+]([O-])=O)C1=O
InChI
1S/C12H10F3N3O4/c1-11(2)9(19)17(10(20)16-11)6-3-4-8(18(21)22)7(5-6)12(13,14)15/h3-5H,1-2H3,(H,16,20)
InChI key
XWXYUMMDTVBTOU-UHFFFAOYSA-N
Gene Information
human ... AR(367)
packaging【包装】
1 g in glass bottle
安全信息
Pictograms【象形图】
GHS06,GHS08
Signal word【警示用语:】
Danger
Hazard Statements
H301 - H360
Precautionary Statements
P201 - P301 + P310 + P330
Hazard Classifications【危险分类】
Acute Tox. 3 Oral - Repr. 1B
Storage Class Code【储存分类代码】
6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
WGK
WGK 3
Personal Protective Equipment【个人防护装备】
Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
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