Monoclonal Anti-Paxillin antibody produced in mouse

MFCD00212475

NA.41

Monoclonal Anti-Paxillin (mouse IgG1 isotype) is derived from the PXC-10 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Paxillin (68 kDa), is a cytoskeletal component. It is found in the ends of actin stress fibers of the focal adhesions, but not in adherens junctions of the cells. The paxillin molecule has a single binding site for vinculin, and at least two binding sites for focal adhesion kinase (FAK), that are separated by an intervening sequence of 100 amino acids.

Recognizes an epitope located in the LIM1 domain of the paxillin molecule.

C-terminal part of recombinant chicken paxillin (amino acids 305-559)

Monoclonal Anti-Paxillin antibody produced in mouse has been used in immunoblotting and immunocytochemistry.

Paxillin interacts with several proteins including members of the src family of tyrosine kinases, the transforming protein v-crk, the cytoskeletal protein vinculin, and the tyrosine kinase, focal adhesion kinase (FAK). This interaction has suggested a function for paxillin as a molecular adaptor, responsible for the recruitment of structural and signaling molecules to focal adhesions.

200

mouse

unconjugated

ascites fluid

primary antibodies

PXC-10, monoclonal

antigen 68-40 kDa

15 mM sodium azide

chicken, human, hamster, bovine, rat

immunocytochemistry: suitable
microarray: suitable
western blot: 1:500 using a cultured human cell line extract

IgG1

P49023

dry ice

−20℃

human ... PXN(5829)
rat ... Pxn(360820)

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