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Monoclonal Anti-Nicotinic Acetylcholine Receptor (α7 Subunit) antibody produced in mouse

产品编号:3149254
规格:~5 mg/mL, clone mAb 306, purified immunoglobulin, buffered aqueous solution
包装规格:100 μL
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
3149254100 μL8350
基本信息
MDL number
MFCD00677279
General description【一般描述】
Nicotinic acetylcholine receptors (nAChRs) function as ligand-gated channels that modulate endoplasmic reticulum stress and neurotransmitter release. These receptors also control synaptic signaling in ganglia and muscles. The α7 form of nAChR is expressed in mitochondria and regulates Ca2+ transport and the release of cytochrome c. When expressed in non-excitable cells, α7 nAChR mediates cell growth and survival
Monoclonal anti-nicotinic acetylcholine receptor ((α7) subunit) antibody is specific for native and denatured α7 subunits in chick, as well as for the denatured α7 subunits in rats and humans. The antibody does not bind well to the native form of the mammalian α7 subunit. The product can be used in chick, rat and human tissues.
Immunogen【免疫原】
native and denatured α7 subunit (amino acids 380-400, binds α-bungarotoxin) of the nicotinic acetylcholine receptor from chicken and the denatured α7 subunit from rat.
Application【应用】
Monoclonal anti-nicotinic acetylcholine receptor ((α7) subunit) antibody is suitable for use in immunocytochemistry (at 1:3000-1:50 dilutions using paraformaldehyde fixed, cultured rat chromaffin cells) , and immunohistochemistry (at 1:3,000 dilutions using frozen sections).
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Physical form【外形】
Solution in 20 mM Na3PO4, pH 7.2, containing 150 mM NaCl and 0.05% sodium azide.
Legal Information【法律信息】
Sold with permission of the Salk Institute
产品性质
Quality Level【质量水平】
100
biological source【生物来源】
mouse
conjugate【偶联物】
unconjugated
antibody form【抗体形式】
purified immunoglobulin
antibody product type
primary antibodies
clone【克隆】
mAb 306, monoclonal
form【形式】
buffered aqueous solution
species reactivity
human (denatured), rat (denatured), chicken
concentration【浓度】
~5 mg/mL
technique(s)
immunohistochemistry (frozen sections): 1:3,000
isotype【同位素/亚型】
IgG1
UniProt accession no.【UniProt登记号】
P36544
shipped in【运输】
dry ice
storage temp.【储存温度】
−20℃
Gene Information
human ... CHRNA7(1139)
rat ... Chrna7(25302)
产品说明
Disclaimer【免责声明】
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
安全信息
Storage Class Code【储存分类代码】
12 - Non Combustible Liquids
WGK
WGK 2
Personal Protective Equipment【个人防护装备】
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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