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Monoclonal Anti-Myocardin antibody produced in mouse
产品编号: | 3148882 |
规格: | ~2.0 mg/mL, clone MCR54, purified immunoglobulin |
包装规格: | 200 μL |
产品类别: | 进口试剂 |
品牌: | Sigma-Aldrich |
优惠价: | 立即咨询 |
产品别名
Monoclonal Anti-Myocardin antibody produced in mouse
Anti-MYOCD
Anti-MYCD
基本信息
NACRES | NA.41 |
General description【一般描述】 | Myocardin (MYOCD) is expressed in the muscles and cardiomyocytes. It is a co-transcriptional factor. Monoclonal Anti-Myocardin (mouse IgG2b isotype) is derived from the hybridoma MCR54 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human myocardin. Myocardin (MYOCD) is a transcriptional coactivator. |
Application【应用】 | Monoclonal Anti-Myocardin antibody produced in mouse has been used in western blot analysisimmunofluorescence. |
Biochem/physiol Actions【生化/生理作用】 | Myocardin (MYOCD) takes part in the differentiation of vascular smooth muscle cells (VSMC). It is a co-factor of serum response factor (SRF) and regulates the activation of those genes which are dependent on SRF. MYOCD forms a complex with SRF on DNA. Myocardin is a smooth and cardiac muscle-specific transcriptional coactivator of serum response factor (SRF). It regulates the expression of a set of cardiac and smooth muscle-specific genes. Myocardin was implicated in the pathogenesis of atherosclerosis, Alzheimer′s disease, and malignant transformation. |
Physical form【外形】 | 0.01M 磷酸缓冲盐溶液,pH 7.4,含 15mM 叠氮化钠。 |
产品性质
Quality Level【质量水平】 | 200 |
biological source【生物来源】 | mouse |
conjugate【偶联物】 | unconjugated |
antibody form【抗体形式】 | purified immunoglobulin |
antibody product type | primary antibodies |
clone【克隆】 | MCR54, monoclonal |
form【形式】 | buffered aqueous solution |
mol wt【分子量】 | antigen ~150 kDa |
species reactivity | human |
packaging【包装】 | antibody small pack of 25 μL |
concentration【浓度】 | ~2.0 mg/mL |
technique(s) | western blot: 2.5-5 μg/mL using HEK-293T cells overexpressing myocardin |
isotype【同位素/亚型】 | IgG2b |
UniProt accession no.【UniProt登记号】 | Q8IZQ8 |
shipped in【运输】 | dry ice |
storage temp.【储存温度】 | −20℃ |
Gene Information | human ... MYOCD(93649) |
产品说明
Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
WGK | WGK 2 |