Monoclonal Anti-MTA2 antibody produced in mouse

MFCD03097137

NA.41

Metastasis associated 1 family member 2 (MTA2) is part of the nucleosome remodeling and histone deacetylation complex. This 668 amino acid protein possesses four different domains.
Monoclonal Anti-MTA2 (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with a synthetic peptide of human MTA2, conjugated to KLH. Human metastasis-associated protein 2 (MTA2) shares 58% homology to human MTA1 and MTA3 proteins, the C-terminus being more divergent than the N-terminus. MTA2 comprises N-terminal bromo-adjacent homology (BAH) and MTA1 homology 2 (ELM2) domain, SANTand zinc finger (ZnF) domain. It also has the nuclear localization region at C-terminus.

synthetic peptide corresponding to amino acids 626-641of human MTA2, conjugated to KLH.

Monoclonal Anti-MTA2 antibody produced in mouse has been used in:

• enzyme linked immunosorbent assay (ELISA)
• immunoprecipitation
• immunocytochemistry
• Western blotting
• antibody microarray

Metastasis associated 1 family member 2 (MTA2) has been associated with tumor progression and metastasis.
Human metastasis-associated protein 2 (MTA2) interacts with the histone deacetylase-1 HDAC1 and within the nuclear remodeling and deacetylation complexes ATP-dependent helicase -nucleosome remodelling and histone deacetylation (Mi2/NuRD), suggests that these proteins are involved in transcriptional repression. In the p53 pathway, MTA2/MTA1L1 is better known as protein in the deacetylase complexes p53 target protein in the deacetylase complexes (PID). It inhibits p53-dependent transcriptional activation and its growth arrest and apoptosis functionality. showing that deacetylation and functional interaction by the PID/MTA2/MTA1L1 associated nucleosome remodeling deacetylase (NuRD) complex may represent an important pathway to regulated p53 function.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

200

mouse

unconjugated

purified immunoglobulin

primary antibodies

MTA2-276, monoclonal

buffered aqueous solution

antigen ~73 kDa

bovine, rat, mouse, human, canine, monkey, hamster

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 1-2 μg/mL using 293T total cell extract

IgG1

O94776

dry ice

−20℃

human ... MTA2(9219)
mouse ... Mta2(23942)
rat ... Mta2(361724)

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12 - Non Combustible Liquids

WGK 3

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)