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Monoclonal Anti-MAGE-1 小鼠抗
Monoclonal Anti-MAGE-1 antibody produced in mouse
| 产品编号： | 3148039 |
| 规格： | ~2 mg/mL, clone MA454, purified immunoglobulin, buffered aqueous solution |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-MAGE-1 小鼠抗
Monoclonal Anti-MAGE-1 antibody produced in mouse
Anti-Melanoma-associatiated antigen 1
基本信息
| MDL number | MFCD03096998 |
| NACRES | NA.41 |
| General description【一般描述】 | Melanoma-associatiated antigen 1 (MAGE-1) is part of the CG (cancer-germline) group of genes and is a tumor-specific antigen. MAGE-1 is a member of the MAGE-A family. MAGE-1 gene is localized on human chromosome Xq28. Monoclonal Anti-MAGE-1 (mouse IgG1 isotype) is derived from the hybridoma MA454 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from mice immunized with human recombinant MAGE-1. |
| Specificity【特异性】 | The antibody does not recognize MAGE-2 and MAGE-3. |
| Immunogen【免疫原】 | recombinant human MAGE-1. |
| Application【应用】 | Monoclonal Anti-MAGE-1 antibody produced in mouse has been used in:
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| Biochem/physiol Actions【生化/生理作用】 | The melanoma antigen genes (MAGE) might play a key role in neural development and apoptosis. Expression of melanoma-associated antigen 1 (MAGE-1) in neoplastic cells depends on the binding of the transcription factor Ets to non-methylated cis regulatory sequences, located in its promoter. MAGE-1 expression is mediatedby the B and B′ domains of MAGE-A1 gene. Expression of MAGE-1A was induced in non MAGE-A1 expressing tumor cells once treated with demethylating reagent, 5-aza-2-(5DC). Melanoma-associatiated antigen 1 (MAGE-1) has been shown to be expressed in different types of cancers. |
| Physical form【外形】 | 0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。 |
产品性质
| Quality Level【质量水平】 | 200 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | MA454, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~46 kDa |
| species reactivity | human |
| packaging【包装】 | antibody small pack of 25 μL |
| concentration【浓度】 | ~2 mg/mL |
| technique(s) | immunohistochemistry: suitable indirect ELISA: suitable western blot: 5-10 μg/mL using total cell extract of SKML37 cells |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | P43355 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... MAGEA1(4100) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, multi-purpose combination respirator cartridge (US) |
