Monoclonal Anti-LIN7A antibody produced in mouse

NA.41

Recombinant protein encompassing a sequence within the center region of human LIN7A.

Suggested starting dilutions are as follows: ICC/IF: 1:100-1:1000, IP: 1:100-1:500, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.

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Purification: Affinity purified by Protein G

Phosphate-buffered saline, no preservative added.

100

mouse

unconjugated

affinity isolated antibody

primary antibodies

GT879, monoclonal

buffered aqueous solution

26kDa

human

1mg/mL

immunoprecipitation (IP): suitable
indirect immunofluorescence: suitable
western blot: 500-3000

IgG1

O14910

wet ice

−20℃

human ... LIN7A(8825)

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12 - Non Combustible Liquids

WGK 1