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Monoclonal Anti-KCNB1 antibody produced in mouse
| 产品编号： | 3147291 |
| 规格： | clone S4-11, 1 mg/mL, purified immunoglobulin |
| 包装规格： | 100 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-KCNB1 antibody produced in mouse
Anti-Kv2.1, S4-11
Anti-Kv2.1
Anti-Kcnb1
Anti-Kcr1-1
Anti-Shab
Anti-DRK1PC
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | The potassium voltage-gated channel subfamily B member 1 (KCNB1) gene is mapped to human chromosome 20q13.13. This gene codes for a α subunit of voltage-gated potassium Kv2.1 channel. The encoded protein contains 858 amino acids and six transmembrane segments (S1–S6). KCNB1 is mainly expressed in the central nervous system, but at high level in somatodendritic compartment of neocortical and pyramidal neurons. |
| Specificity【特异性】 | Detects ~105-125 kDa. Recognizes the Shab related α-subunit Kv2.1. |
| Immunogen【免疫原】 | Bacterially expressed GST Bacterially expressed GSTfusion protein corresponding toamino acids 509-853 of rat KV2.1, Accession Number NM_004975. |
| Biochem/physiol Actions【生化/生理作用】 | Potassium voltage-gated channel subfamily B member 1 (KCNB1) plays a vital role in hippocampal neuron excitation homeostasis. The encoded protein is mainly implicated in the generation of the major delayed rectifier potassium current in pyramidal neurons. Mutation in the gene is associated with the development of left ventricular (LV) hypertrophy and early-onset infantile epilepsy in humans. |
| Features and Benefits【特点和优势】 | Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more. |
| Physical form【外形】 | Solution in PBS, pH 7.4, 50% glycerol, and 0.09% sodium azide |
产品性质
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | S4-11, monoclonal |
| form【形式】 | buffered aqueous glycerol solution |
| mol wt【分子量】 | antigen predicted mol wt 105-125 kDa |
| species reactivity | rat, monkey, human, mouse |
| concentration【浓度】 | 1 mg/mL |
| technique(s) | immunocytochemistry: suitable immunohistochemistry: suitable immunoprecipitation (IP): suitable western blot: suitable |
| isotype【同位素/亚型】 | IgG1 |
| NCBI accession no.【NCBI登记号】 | NP_037318 |
| UniProt accession no.【UniProt登记号】 | Q14721 |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | rat ... Kcnb1(25736) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
| WGK | WGK 1 |
