Anti-IFI-16 antibody, Mouse monoclonal antibody produced in mouse

MFCD07785406

NA.41

The gene IFI-16 (interferon, γ-inducible protein 16) encodes a member of the interferon-inducible nuclear proteins family containing one or two copies of a conserved 200 amino acid repeat domain called HIN-200 domain. It has three different isoforms, IFI-16A, -16B, -16C. The IFI-16A isoform is the longest with 785 amino acids. IFI-16B is the most broadly expressed isoform with 729 amino acids and IFI-16C has 56 amino acids lesser. The three isoforms have serine and threonine residues which can be phosphorylated. The N-terminus contains an imperfect leucine zipper domain, where the isoforms homo- and heterodimerize. IFI-16 contains an N-terminal domain called DAPIN/PYRIN/CARD that may be involved in protein–protein interactions. IFI-16 is expressed in some haemopoietic lineages , such as CD34+ progenitor cells, mature lymphocytes and monocytes. The gene is mapped to human chromosome 1q22.

synthetic peptide corresponding to amino acids 768-783 at the C-terminus of human IFI-16.

The gene IFI-16 (interferon, γ-inducible protein 16) encodes an interferon-inducible transcriptional modulator from the p200-protein family. It may play a role in negative regulation of transcription. Overexpression of this gene in older populations of human fibroblasts leads to cellular senescence. It is also associated with senescence-associated irreversible cell growth arrest in normal human prostate epithelial cells.

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

200

mouse

unconjugated

purified from hybridoma cell culture

primary antibodies

IFI-230, monoclonal

buffered aqueous solution

antigen 85-95 kDa (cluster of three isotypes A, B, and C)

human

~1 mg/mL

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 0.5-1 μg/mL using whole extract of the Jurkat cell line

Q16666

dry ice

−20℃

human ... IFI16(3428)

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