Monoclonal Anti-IDH1 antibody produced in mouse

NA.41

Isocitrate dehydrogenase 1 (IDH1) is encoded by the gene mapped to human chromosome 2q34. It is a member of the isocitrate dehydrogenase enzymes family. IDH1 is mainly found in cytoplasm and peroxisomes.

IDH1 purified recombinant protein

Isocitrate dehydrogenase 1 (IDH1) acts as a regulator of cytoplasmic and peroxisomal lipid metabolism in various tissues. It catalyzes the conversion of isocitrate to α-ketoglutarate, which is a key cofactor for 2-OG-dependent dioxygenases. IDH1 facilitates various cellular processes such as adaptation to hypoxia, histone demethylation and DNA modification. It is also involved in the synthesis of plasmalogen lipids in peroxisomes. Somatic mutation of the gene is associated with the development of gliomas and acute myeloid leukaemia (AML).

Solution in Dulbecco′s Modified Eagle′s Medium with 10% fetal calf serum and 15 mM sodium azide.

mouse

unconjugated

culture supernatant

primary antibodies

IDH1-A36, monoclonal

aqueous solution

antigen predicted mol wt 46.7 kDa

human

western blot: suitable

IgG1

O75874

dry ice

−20℃

human ... IDH1(3417)

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12 - Non Combustible Liquids

WGK 3