Monoclonal Anti-EIF4EBP1 antibody produced in mouse

NA.41

The gene EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) is mapped to human chromosome 8p12.

Purified recombinant fragment of 4EBP1 expressed in E.coli.
Mouse monoclonal antibody raised against 4E-BP1

The gene EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) encodes a translation repressor that interacts with eukaryotic translation initiation factor 4E (eIF4E). eIF4E is a multisubunit complex that recruits 40S ribosomal subunits to the 5′ end of mRNA. The interaction of the encoded binding protein with this complex inhibits translation. The phosphorylation of eIF4Ebp1 in response to stimuli such as, UV irradiation and insulin signaling, results in dissociation of this factor from the eIF4E complex, leading to initiation of translation of mRNA. The encoded protein participates in cell proliferation, apoptosis, invasion, and metastasis. It functions as an effector molecule in mTOR (mammalian target of rapamycin complex 1) signaling pathway that regulates protein synthesis. It is found to be overexpressed in hepatocellular carcinoma tissues and serves as a potential prognostic and therapeutic target.

Ascitic fluid containing 0.03% sodium azide.

100

mouse

unconjugated

ascites fluid

primary antibodies

11G12C11, monoclonal

human

direct ELISA: 1:10,000
immunohistochemistry: 1:200-1:1,000
western blot: 1:500-1:2,000

IgG1

wet ice

−20℃

human ... 4E-BP1(1978)

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12 - Non Combustible Liquids

WGK 3