Monoclonal Anti-CHD5 antibody produced in rat

NA.41

Monoclonal Anti-CHD5 (rat IgG2a isotype) is derived from the hybridoma 5A10 produced by the fusion of mouse myeloma cells and lymph node cells from rat immunized with a synthetic peptide corresponding to a sequence at the C-terminal region of human CHD5. Chromodomain helicase DNA(CHD) binding protein 5 (CHD5) is an ATP-dependent chromatin-remodeling factor. It is mainly expressed in neuronal tissues. CHD5 is a member of CHD family of proteins that is characterized with histone binding chromo (chromatin organization modifier) domains and sucrose non-fermentable 2 (SNF2)-related helicase/ATPase domains.

synthetic peptide corresponding to a sequence at the C-terminal region of human CHD5 .

Monoclonal Anti-CHD5 antibody produced in rat has been used in various immunochemical techniques including:

• immunoblotting
• flow cytometry
• immunocytochemistry
• immunohistochemistry

Chromodomain helicase DNA binding protein 5 (CHD5) regulates genes involved in neuronal function, cell-cycle control, and chromatin remodeling. Interestingly, CHD5 is frequently deleted in neuroblastoma and thus suggested as a tumor suppressor gene. Furthermore, non-conformist CHD5 promoter methylation was identified in several primary tumors.

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

200

rat

purified immunoglobulin

primary antibodies

5A10, monoclonal

buffered aqueous solution

~250 kDa

monkey, mouse, human

~1 mg/mL

flow cytometry: 2.5-5 μg/test using using HeLa cells.
immunoblotting: 1.0-2.0 μg/mL using using whole extracts of L929 cells.
immunofluorescence: 5-10 μg/mL using using HeLa cells.

IgG2a

Q8TDI0

dry ice

−20℃

Monkey ... CHD5(720712)
human ... CHD5(26038)
mouse ... 269610(Chd5)

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12 - Non Combustible Liquids

WGK 1