Monoclonal Anti-CD95 antibody produced in mouse

NA.41

CD95, also known as Fas (fatty acid synthase) cell surface death receptor/APO-1, is encoded by the gene mapped to human chromosome 10q23.31. The encoded protein belongs to the tumor necrosis factor receptor superfamily and is expressed on a variety of cells including activated T and B cells. CD95 contains a death domain.
The antibody LT95 reacts with CD95 (Fas/APO-1), a 46 kDa single chain type I glycoprotein of the tumour necrosis factor/nerve growth factor (TNF/NGF) receptor superfamily, expressed on a variety of normal and neoplastic cells. It seems that the antibody LT95 does not induce Fas mediated apoptosis, although it cross-blocks anti-Fas DX2 antibody that recognizes a functional epitope of Fas molecule.

HUT-78 human T cell lymphoma cell line

Monoclonal Anti-CD95 antibody produced in mouse has been used as a apoptosis inducer.

CD95/ Fas (fatty acid synthase) cell surface death receptor interacts with its natural ligand (FasL/CD95 L) and plays a vital role in regulation of T-cell homeostasis, by promoting apoptosis via activation-induced cell death (AICD). Mutation in the gene has been associated with the development of Sézary syndrome (SS) and Canale–Smith syndrome. CD95 gene loss can be used as a genetic marker of PSA recurrence after radical prostatectomy.

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.

mouse

unconjugated

purified immunoglobulin

primary antibodies

LT95, monoclonal

buffered aqueous solution

human

1 mg/mL

flow cytometry: suitable

IgG1

NM_000043.3

P25445

wet ice

2-8℃

human ... FAS(355)

12 - Non Combustible Liquids

WGK 1