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Anti-BRD7 antibody, Rat monoclonal
| 产品编号： | 3141795 |
| 规格： | clone BRM 2D3, purified from hybridoma cell culture |
| 包装规格： | 200 μL |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Anti-BRD7 antibody, Rat monoclonal
Anti-BP75
Monoclonal Anti-BRD7 antibody produced in rat
Anti-NAG4
Anti-Bromodomain containing 7
Anti-CELTIX1
基本信息
| NACRES | NA.41 |
| General description【一般描述】 | Monoclonal Anti-BRD7 (rat IgG2a isotype) is derived from the hybridoma BRM 2D3 produced by the fusion of mouse myeloma cells (P3X63Ag8.653) and splenocytes from rat immunized with a fusion protein expressing a fragment of human BRD7. Bromodomain containing (BRD7) is a novel bromodomain gene. |
| Application【应用】 | Monoclonal Anti-BRD7 antibody produced in rat has been used in several immunochemical techniques including
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| Biochem/physiol Actions【生化/生理作用】 | Bromodomain containing (BRD7) inhibits cell growth and cell cycle progression by transcriptional regulation of some cell cycle-related genes as well as some important molecules involved in ras/mitogen-activated protein kinase(MEK)/extracellular-signal-regulated kinase (ERK) and retinoblastoma tumor suppressor protein (RB)/ E2 factor (E2F) pathways. Its transcriptional down regulation has been shown to be critical to the pathogenesis of nasopharyngeal carcinoma (NPC). Specifically, DNA methylation decreases the expression of BRD7 in NPC cells. Furthermore, DNA methylation of BRD7 promoter is increased in the tumor and in matched blood samples from NPC patients than in blood samples from healthy individuals. Therefore, it has been suggested that DNA methylation of BRD7 promoter might act as a potential diagnostic marker in NPC. |
| Physical form【外形】 | Solution in 0.01M phosphate buffered saline pH 7.4, containing 15 mM sodium azide. |
产品性质
| biological source【生物来源】 | rat |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified from hybridoma cell culture |
| antibody product type | primary antibodies |
| clone【克隆】 | BRM 2D3, monoclonal |
| form【形式】 | buffered aqueous solution |
| mol wt【分子量】 | antigen ~80 kDa |
| species reactivity | human, bovine, canine, monkey, rat, mouse |
| packaging【包装】 | antibody small pack of 25 μL |
| technique(s) | immunocytochemistry: suitable immunoprecipitation (IP): suitable western blot: 0.5-1.0 μg/mL using HeLa cells extract |
| isotype【同位素/亚型】 | IgG2a |
| UniProt accession no.【UniProt登记号】 | Q9NPI1 |
| shipped in【运输】 | dry ice |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... BRD7(29117) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 12 - Non Combustible Liquids |
