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Monoclonal Anti-Brain-derived Neurotrophic Factor antibody produced in mouse
| 产品编号： | 3141783 |
| 规格： | clone 35909, purified immunoglobulin, lyophilized powder |
| 包装规格： | 500 μG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品别名
Monoclonal Anti-Brain-derived Neurotrophic Factor antibody produced in mouse
Anti-BDNF
基本信息
| MDL number | MFCD01633045 |
| General description【一般描述】 | Brain derived neurotrophic factor (BDNF) belongs to a family of secreted proteins called neurotrophins that includes, nerve growth factor (NGF), neurotrophin-3 (NT3) and NT4/5. BDNF is expressed in the developing and the mature brain. The influence of BDNF is mediated by its binding to TrkB receptor and sometimes the receptor p75NTR. The downstream pathways promoted by BDNF include PI3K, MAPK and JAK/STAT. The most important role of BDNF is the regulation of synaptic transmission and plasticity, protein synthesis and phosphorylation of local proteins. The secretion of BDNF is highly regulated at both transcriptional and translational levels since it is involved in the proper function of neuronal circuit and development of cognitive functions. The deficits in BDNF functions are implicated in a number of neurodegenerative disorders such as Huntington′s disease, schizophrenia and dementia Monoclonal Anti-Brain-derived Neurotrophic Factor detects human BDNF. |
| Immunogen【免疫原】 | purified, Sf21-derived recombinant human brain-derived neurotrophic factor. |
| Application【应用】 | Monoclonal Anti-Brain-derived Neurotrophic Factor may be used to detect human BDNF by flow cytometry using a working antibody concentration of 25 μg/ml. |
| Physical form【外形】 | Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | mouse |
| conjugate【偶联物】 | unconjugated |
| antibody form【抗体形式】 | purified immunoglobulin |
| antibody product type | primary antibodies |
| clone【克隆】 | 35909, monoclonal |
| form【形式】 | lyophilized powder |
| species reactivity | human |
| technique(s) | flow cytometry: 25 μg/mL |
| isotype【同位素/亚型】 | IgG1 |
| UniProt accession no.【UniProt登记号】 | P23560 |
| storage temp.【储存温度】 | −20℃ |
| Gene Information | human ... BDNF(627) |
产品说明
| Disclaimer【免责声明】 | Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| Personal Protective Equipment【个人防护装备】 | Eyeshields, Gloves, type N95 (US) |
