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M30 dihydrochloride
产品别名
64821-19-8
M30 dihydrochloride
VAR10300 dihydrochloride
M-30 dihydrochloride
5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C14H14N2O · 2HCl |
| Molecular weight | 299.20 |
| MDL number | MFCD20488063 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825178 |
| NACRES | NA.77 |
| Application【应用】 | M30 dihydrochloride may be used in monamine oxidase-mediated cell signaling studies. |
| Biochem/physiol Actions【生化/生理作用】 | M30 is a site-activated iron chelator and monoamine oxidase (MAO) inhibitor; with neuroprotective and anti-apoptotic activity. It is a multifunctional non-toxic, brain permeable iron chelator possessing a neuroprotective propargylamine moiety and an antioxidant-iron chelator moiety. M30 is a selective irreversible inhibitor of mitochondrial brain monoamine oxidases A and B (MAO-A and -B), providing for improved levels of neurotransmitters. It reduces oxidative damage and shows neuroprotective and neurorestorative effects in various neurodegenerative models of ALS, Alzheimer′s and Parkinson′s diseases, and is being investigated in other diseases where oxidative stress is a problem. |
| Features and Benefits【特点和优势】 | This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| color【颜色】 | green-yellow |
| solubility【溶解性】 | DMSO, heptane and xylene: ≥21 mg/mL |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | Cl.Cl.CN(CC#C)Cc1ccc(O)c2ncccc12 |
| InChI | 1S/C14H14N2O.2ClH/c1-3-9-16(2)10-11-6-7-13(17)14-12(11)5-4-8-15-14;;/h1,4-8,17H,9-10H2,2H3;2*1H |
| InChI key | XJNICPXVRPOSSO-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS05,GHS07 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H302 - H318 |
| Precautionary Statements | P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral - Eye Dam. 1 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
