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Irbesartan
| 产品编号： | 3100054 |
| 规格： | ≥98% (HPLC), powder |
| CAS NO： | 138402-11-6 |
| 包装规格： | 10 MG，50 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3100054 | 10 MG | 1300 | |||
| 3100054 | 50 MG | 3630 |
产品别名
138402-11-6
Irbesartan
BMS-186295
SR-47436
2-Butyl-3-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one
Avapro
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H28N6O |
| Molecular weight | 428.53 |
| MDL number | MFCD00864464 |
| PubChem Substance ID【PubChem化学物质编号】 | 329815365 |
| NACRES | NA.77 |
| General description【一般描述】 | Irbesartan comprises bipentyl-tetrazole side chain. It is an imidazole derivative with high bioavailability and is metabolized by the enzyme cytochrome P450 2C9 isoenzyme in liver to be majorly eliminated by oxidation and glucuronidation. |
| Application【应用】 | Irbesartan has been used as an angiotensin II receptor type 1 (ATR1) blocker in carotid atheroma tissue. It may be used to test its effect on allergic asthma in rat and mice mast cells. |
| Biochem/physiol Actions【生化/生理作用】 | Irbesartan is an angiotensin II type 1 (AT1) receptor antagonist with antihypertensive activity. It also elicits selective peroxisome proliferator-activated receptor γ (PPARγ)-modulating activity and possesses anti-inflammatory properties. Irbesartan shows protective cardiovascular effects and provides protection against chronic glomerulonephritis. |
| Features and Benefits【特点和优势】 | This compound was developed by Bristol-Myers Squibb and Sanofi Aventis. To browse the list of other pharma-developed compounds, Approved Drugs, and Drug Candidates, click here. This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to off-white |
| solubility【溶解性】 | DMSO: >25 mg/mL |
| originator【创始人】 | Bristol-Myers Squibb Sanofi Aventis |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CCCCC1=NC2(CCCC2)C(=O)N1Cc3ccc(cc3)-c4ccccc4-c5nnn[nH]5 |
| InChI | 1S/C25H28N6O/c1-2-3-10-22-26-25(15-6-7-16-25)24(32)31(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)23-27-29-30-28-23/h4-5,8-9,11-14H,2-3,6-7,10,15-17H2,1H3,(H,27,28,29,30) |
| InChI key | YOSHYTLCDANDAN-UHFFFAOYSA-N |
| Gene Information | human ... AGTR1(185) |
| packaging【包装】 | 10, 50 mg in glass bottle |
安全信息
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
