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HI-TOPK-032
产品别名
487020-03-1
HI-TOPK-032
N-(12-Cyanindolizino[2,3-b]quinoxalin-2-yl)-2-thiophenecarboxamide
基本信息
| Empirical Formula【经验(实验)分子式】 | C20H11N5OS |
| Molecular weight | 369.40 |
| NACRES | NA.77 |
| Application【应用】 | HI-TOPK-032 has been used as a PDZ binding-kinase (PBK) inhibitor. |
| Biochem/physiol Actions【生化/生理作用】 | HI-TOPK-032 is a specific TOPK (T-LAK cell–originated protein kinase) inhibitor both in vitro and in vivo. HI-TOPK-032 suppressed tumor growth in a colon cancer xenograft model. HI-TOPK-032 belongs to the class of ATP-competitive inhibitors. It can also be used as a potent therapeutic for colorectal cancer. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | orange to dark red |
| solubility【溶解性】 | DMSO: 3 mg/mL, clear (warmed) |
| storage temp.【储存温度】 | 2-8℃ |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS07 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H302 |
| Hazard Classifications【危险分类】 | Acute Tox. 4 Oral |
| Storage Class Code【储存分类代码】 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
