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GW788388 Hydrate
产品别名
GW788388 Hydrate
4-{4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]-pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide hydrate
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H23N5O2 · xH2O |
| Molecular weight | 425.48 (anhydrous basis) |
| MDL number | MFCD20527321 |
| PubChem Substance ID【PubChem化学物质编号】 | 329825168 |
| Biochem/physiol Actions【生化/生理作用】 | GW788388 is a potent selective inhibitor of TGF-beta type I receptor [activin receptor-like kinase 5 (ALK5)]. GW788388 is orally available with a half-life of approximately 4 hours. |
| Features and Benefits【特点和优势】 | This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| color【颜色】 | white to tan |
| solubility【溶解性】 | DMSO: ≥8 mg/mL |
| originator【创始人】 | GlaxoSmithKline |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | O.O=C(NC1CCOCC1)c2ccc(cc2)-c3cc(ccn3)-c4c[nH]nc4-c5ccccn5 |
| InChI | 1S/C25H23N5O2.H2O/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22;/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31);1H2 |
| InChI key | VZRJMBZMFKADGR-UHFFFAOYSA-N |
| packaging【包装】 | 5, 25 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06,GHS09 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H301 - H400 |
| Precautionary Statements | P273 - P301 + P310 + P330 |
| Hazard Classifications【危险分类】 | Acute Tox. 3 Oral - Aquatic Acute 1 |
| Storage Class Code【储存分类代码】 | 6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects |
| WGK | WGK 3 |
