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Gold nanoparticles

产品编号:3092046
规格:40 nm diameter, amine functionalized, PEG 3000 coated, OD 50, dispersion in H2O
包装规格:1 ML
产品类别:进口试剂
品牌:Sigma-Aldrich
优惠价:立即咨询
产品价格
产品编号包装单位单价(元)国内现货国外库存询价单
30920461 ML4770
产品别名

Gold nanoparticles

Gold nanoparticles NH2 functionalized

Gold Colloid

Au NP NH2

结构式
基本信息
NACRES
NA.23
General description【一般描述】
Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.
Application【应用】
Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:
  • Since they adheres to cell membranes, AuNPs are used in cellular and intracellular targeting in targeted drug delivery applications and may also be used in biodistribution studies
  • AuNPs may also be used in photothermal therapy and radiotherapy.
  • They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.
Features and Benefits【特点和优势】
  • A negatively charged siRNA-PEG complex attached to a positively charged GNPs is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.
  • The PEG coating decreases the cytotoxicity and increases effciciency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.
产品性质
Quality Level【质量水平】
100
material【物料】
PEG 3000
form【形式】
dispersion in H2O
nanoparticles
OD
50
Diameter【直径】
40 nm
pH【pH值(酸碱度)】
6.0-8.0 (25 ℃)
solubility【溶解性】
water: miscible
density
1.00 g/cm3
λmax
530 nm
functional group【官能团】
amine
storage temp.【储存温度】
2-8℃
packaging【包装】
1 mL in poly bottle
安全信息
Storage Class Code【储存分类代码】
10 - Combustible liquids
WGK
WGK 1
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