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GF 109203X
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| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3090610 | 1 MG | 11190 |
产品别名
133052-90-1
GF 109203X
3-(N-[Dimethylamino]propyl-3-indolyl)-4-(3-indolyl)maleimide
Bisindolylmaleimide I
3-[1-[3-(Dimethylamino)propyl]1H-indol-3-yl]-4-(1Hindol-3-yl)1H-pyrrole-2,5dione
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C25H24N4O2 |
| Molecular weight | 412.48 |
| MDL number | MFCD00236428 |
| PubChem Substance ID【PubChem化学物质编号】 | 329799908 |
| NACRES | NA.77 |
| Application【应用】 | GF 109203X has been used as a protein kinase C inhibitor in HUVECs (human umbilical vein endothelial cells), angiotensinogen gene knockout (AGT KO) mice, and in granulosa cell cultures of female rats. |
| Biochem/physiol Actions【生化/生理作用】 | A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). Inhibits parathyroid hormone-induced Ca2+ resorption from isolated bone tissue, Staurosporine, another protein kinase inhibitor, actually enhanced Ca2+ resorption elicited by a number of agents, but GF109203X counteracted that enhancement. A potent and selective competitive inhibitor of protein kinase C (PKC) and of glycogen synthase kinase-3 (GSK-3). In certain cells, inhibition of PKC leads to an increase in autophagy. For PKC inhibition, typically used at a concentration of 0.1-10 μM. |
| Quantity【数量】 | For PKC inhibition, typically used at a concentration of 0.1-10 μM. |
产品性质
| Quality Level【质量水平】 | 100 |
| biological source【生物来源】 | synthetic |
| Assay【测定】 | ≥90% (HPLC) |
| solubility【溶解性】 | DMSO: soluble (~1 mg/ml) |
| storage temp.【储存温度】 | 2-8℃ |
| SMILES string | CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15 |
| InChI | 1S/C25H24N4O2/c1-28(2)12-7-13-29-15-19(17-9-4-6-11-21(17)29)23-22(24(30)27-25(23)31)18-14-26-20-10-5-3-8-16(18)20/h3-6,8-11,14-15,26H,7,12-13H2,1-2H3,(H,27,30,31) |
| InChI key | QMGUOJYZJKLOLH-UHFFFAOYSA-N |
安全信息
| Pictograms【象形图】 | GHS08 |
| Signal word【警示用语：】 | Warning |
| Hazard Statements | H351 |
| Precautionary Statements | P201 - P202 - P280 - P308 + P313 - P405 - P501 |
| Hazard Classifications【危险分类】 | Carc. 2 |
| Supp Hazards【补充剂危害】 | EUH019 |
| Storage Class Code【储存分类代码】 | 11 - Combustible Solids |
| WGK | WGK 3 |
