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度骨化醇
Doxercalciferol
| 产品编号： | 3079866 |
| 规格： | ≥98% (HPLC), solubility: >10 mg/mL in DMSO |
| CAS NO： | 54573-75-0 |
| 包装规格： | 1 MG，5 MG |
| 产品类别： | 进口试剂 |
| 品牌： | Sigma-Aldrich |
| 优惠价： | 立即咨询 |
产品价格查看更多规格...
| 产品编号 | 包装单位 | 单价(元) | 国内现货 | 国外库存 | 询价单 |
| 3079866 | 1 MG | 1330 | |||
| 3079866 | 5 MG | 4840 |
产品别名
54573-75-0
度骨化醇
Doxercalciferol
1α-Hydroxyergocalciferol
1α-Hydroxyvitamin D2
1α-OHD2
TSA 840
1-α-Hydroxyvitamin D2
1-Hydroxyergocalciferol
(5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1α,3β-diol
(5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diol
结构式
基本信息
| Empirical Formula【经验(实验)分子式】 | C28H44O2 |
| Molecular weight | 412.65 |
| MDL number | MFCD00871065 |
| PubChem Substance ID【PubChem化学物质编号】 | 329798592 |
| NACRES | NA.77 |
| Biochem/physiol Actions【生化/生理作用】 | Doxercalciferol is a Vitamin D2 analogue, a Vitamin D Receptor Activator (VDRA). Doxercalciferol acts as a pro-hormone, needing 25-hydroxylation in the liver for bioactivation into 1α, 25-hydroxyvitamin D2. Pivotal studies in adults on dialysis have demonstrated control of secondary hyperparathyroidism that is superior to placebo therapy, without undue suppression of 1st IMA-PTH < 300 pg/mL, or occurrences of hypercalcemia. Doxercalciferol has been shown to be effective in controlling secondary hyperparathyroidism of adult patients with CKD stages 3-4. Doxercalciferol is a vitamin D2 analog that acts as a pro-hormone, activated in the liver to 1α,25-dihydroxyvitamin D2. Despite its relatively low affinity for the vitamin D receptor (VDR) (before activation), it is effective at suppressing expression of the parathyroid hormone (PTH) gene, and appears to act through the VDR. |
产品性质
| Quality Level【质量水平】 | 100 |
| Assay【测定】 | ≥98% (HPLC) |
| form【形式】 | powder |
| storage condition【储存条件】 | desiccated |
| solubility【溶解性】 | DMSO: >10 mg/mL |
| shipped in【运输】 | wet ice |
| storage temp.【储存温度】 | −20℃ |
| SMILES string | CC(C)[C@@H](C)\C=C\[C@@H](C)[C@H]1CC[C@H]2C(\CCC[C@]12C)=C\C=C3\C[C@@H](O)C[C@H](O)C3=C |
| InChI | 1S/C28H44O2/c1-18(2)19(3)9-10-20(4)25-13-14-26-22(8-7-15-28(25,26)6)11-12-23-16-24(29)17-27(30)21(23)5/h9-12,18-20,24-27,29-30H,5,7-8,13-17H2,1-4,6H3/b10-9+,22-11+,23-12-/t19-,20+,24+,25+,26-,27-,28+/m0/s1 |
| InChI key | HKXBNHCUPKIYDM-CGMHZMFXSA-N |
| Gene Information | human ... VDR(7421) |
| packaging【包装】 | 1, 5 mg in glass bottle |
安全信息
| Pictograms【象形图】 | GHS06 |
| Signal word【警示用语：】 | Danger |
| Hazard Statements | H300 |
| Precautionary Statements | P264 - P301 + P310 |
| Hazard Classifications【危险分类】 | Acute Tox. 1 Oral |
| Storage Class Code【储存分类代码】 | 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
| WGK | WGK 3 |
