吡啶-2,3-二甲酸

Quinolinic acid is an endogenous NMDA agonist. Quinolinic acid is a metabolite of tryptophan that acts as a putative NMDA receptor agonist. Quinolinic acid is an ?“excitotoxic?” metabolite and an agonist of N-methyl-D-aspartate receptors. properties of KYNA raise the possibility of a functional link between KYNA and QUIN in the brain which may be of relevance for an understanding of human neurodegenerative disorders. Quinolinic acid is a potent endogenous excitant at amino acid receptors in CNS.

Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

MFCD00006295

201-874-8

C₇H₅NO₄

167.12

ca 188° dec.

Ambient temperatures.

Crystalline powder

Soluble in water (partly), alkalies, dilute aqueous base, DMSO, and alcohol (slightly).

137110

14,8073

36/37/38
Irritating to eyes, respiratory system and skin.

26-37
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.

US7967250

是

 

H315-H319-H335
Causes skin irritation.Causes serious eye irritation.May cause respiratory irritation.

P261-P280a-P305+P351+P338-P304+P340-P405-P501a
Avoid breathing dust/fume/gas/mist/vapours/spray.Wear protective gloves and eye/face protection.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.IF INHALED: Remove to fresh air and keep at rest in a position comfortable for breathing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.