4-(氯甲基)吡啶盐酸盐

It finds its application as a reagent for protection of carboxyl termini of peptides as 4-picolyl esters, providing a polar 'handle' which aids in separation and purification of the peptide. The group can be introduced in the presence of a base, e.g. tetramethylguanidine, is stable to acid-catalyzed removal of Cbz protecting group and can be removed by base, Na in liquid ammonia or catalytic hydrogenolysis. It is also applied in conjunction with Amberlyst??15 resin in peptide synthesis. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals and agrochemicals.

Hygroscopic. Store away from oxidizing agents and bases. Keep the container tightly closed and place it in a cool, dry and well ventilated condition.

MFCD00012826

217-350-7

C₆H₆₂N?HCl

164.04

166-171°

Hygroscopic. Ambient temperatures.

Crystalline powder

Soluble in water (750 mg/ml at 20°C), soluble in 1N HCl (2.5%), DMSO, and methanol.

3689154

III

21/22-34-43
Harmful in contact with skin and if swallowed.Causes burns.May cause sensitization by skin contact.

8

24-26-36/37/39-45
Avoid contact with skin.In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

  

否

  

H301-H311-H314-H318-H317
Toxic if swallowed.Toxic in contact with skin.Causes severe skin burns and eye damage.Causes serious eye damage.May cause an allergic skin reaction.

P260h-P301+P310a-P303+P361+P353-P305+P351+P338-P405-P501a
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Store locked up.Dispose of contents/container in accordance with local/regional/national/international regulations.