3-氯-5-氟苯酚

3-Chloro-5-fluorophenol is used as an intermediate in organic synthesis. It plays an important role in the preparation of substituted amides as antagonists and/or inverse agonists of cannabinoid-1 receptor, substituted N-(arylmethyl)aryloxy arylcarboxamide and heteroarylcarboxamide antagonists for the PGE2 receptor EP4 for the treatment of pain, inflammation, osteoarthritis, and rheumatoid arthritis.

Incompatible with strong oxidizing agents.

MFCD00042212

None

C₆H₄ClFO

146.55

1.537

Ambient temperatures.

Liquid

Immiscible with water.

III

21/22-34-51/53
Harmful in contact with skin and if swallowed.Causes burns.Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.

8

26-36/37/39-45-61
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.Wear suitable protective clothing, gloves and eye/face protection.In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).Avoid release to the environment. Refer to special instructions/safety data sheets.

   

否

   

H302-H312-H314-H318-H401-H411
Harmful if swallowed.Harmful in contact with skin.Causes severe skin burns and eye damage.Causes serious eye damage.Toxic to aquatic life.Toxic to aquatic life with long lasting effects.

P273-P280-P303+P361+P353-P305+P351+P338-P310
Avoid release to the environment.Wear protective gloves/protective clothing/eye protection/face protection.IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.Immediately call a POISON CENTER or doctor/physician.